Sheila_Fitzgerald / Shutterstock.com Nail Polish Remover Hazardous Waste Illegal in Garbage & Drains Sheila_Fitzgerald / Shutterstock.com Unused or leftover nail polish remover should be disposed of as household hazardous waste. Find out what to do with household hazardous waste Don’t Dump Down the Drain The EPA considers nail polish remover to be hazardous waste, and it needs to be disposed of as such. So to keep waterways clean, definitely do not dump it down the drain. Did You Know? Why So Cold? Acetone, the chemical in traditional nail polish remover, feels cold on your skin because of the speed at which it evaporates. Evaporation draws heat out, leaving a cold feeling behind.